Estrogen and Weight Gain: How Hormones Affect Midlife Weight—and What to Do

By
Papayya Team
September 1, 2025

The Hormonal Reality of Midlife Weight Gains—and How to Reclaim Control

Perimenopause sneaks up on you until you can't deny it anymore. Perhaps you're in your early 40s or mid-50s—or perhaps even younger—and suddenly your body has a different narrative. Hormones fluctuate wildly. Energy fades. Weight gains stubbornly around your waistline. Clothing becomes tighter. Muscles respond less than before. And sleep? Let's not even start.

But here's the empowering truth: this isn't a moment to slow down. It's a moment to move ahead—with intention, awareness, and understanding.

And you don't need to go it alone. Papayya certified trainers lead you through what your shifting hormones do to your weight, and construct habits to work with your changing body.

What Estrogen Does—and why losing it can feel like you're losing yourself

Estrogen is not only for reproduction, it is a metabolic powerhouse. When you are in your reproductive years, it directs fat to be stored on your hips and thighs, enhances muscle tone, and communicates hunger. However, then those hormones start to drop during perimenopause and menopause, you experience an actual shift. You see an increase in fat accumulation around the abdomen, more atrophy of muscle, and reduced metabolic rates.

 

Estradiol, your most potent form of estrogen, decreases dramatically during this time. Contrary to other hormone changes, this decline derails metabolic function, appetite regulation, and fat distribution in significant waysVogue. It also impacts insulin control, making it more difficult to control blood sugar and encouraging fat storage rather than fuel burning

Start a free 7- to 14-day trial with Papayya with a coach who knows your goals and preferences.

Your Weight Shift Might Be Hormonal: How to Know

How do you know if your weight gain is estrogen-driven? Look out for these telltale signs:

  • Excess belly fat ("menopause belly")
  • Weight gain despite eating as you used to
  • Cravings for sugar and carbs
  • Mood swings, nervousness, or lack of energy
  • Sleep disruption due to night sweats
  • Unexplained exhaustion

When these symptoms accompany midlife, estrogen decline is often the culprit. It's not laziness—it’s biology.

Why Traditional Diets and Workouts Fall Short

Eating less and exercising more used to work in your 20s and 30s, but now they often backfire. Here’s why those methods might be counterproductive:

  • Low-calorie diets can trigger cortisol—which promotes fat storage and muscle loss.
  • Endurance cardio marathons stress your adrenals and can disrupt hormone balance.
  • Disregarding stress and sleep sabotages metabolism and inspires cravings.

The Science: Estrogen, Metabolism & Fat Distribution

Let's get into the science:

A review in Climacteric establishes estrogen loss during menopause causes central fat gain, and hormone therapy (HT) can limit fat buildup and enhance insulin sensitivity

Menopause Journal studies indicate up to 70% of women experience ~2.1 kg (approximately 4.6 lb) weight gain during menopause, largely from fat—not muscle.

In other words: this isn't make-believe. It's genetically, hormonally, scientifically real. 

How to Create a Hormone-Smart Weight Plan

This is how to create a plan that suits your changing body:

1. Strength training: Build a strong base

How this works: strength training helps keep your muscle, maintain your bone density and raise your resting metabolism to counteract muscle loss caused by low estrogen.

  • How to get started: 2-3 full body workouts per week
  • What exercises: squats, lunges, push-ups, rows
  • What tools: dumbbells, bands, bodyweight

2. Talk to your doctor about hormone therapy (if indicated) 

If your doctor recommends hormone therapy (HT) it will reduce belly fat and improve the cell's response to insulin, research has shown it reduces gain in visceral fat by almost 60%

3. Stress Management: Stop feeding Cortisol

High cortisol = fat on bum, belly, while thighs and arms are skinny! What can you do to calm your mind and stop habits (deep breathing, yoga, daily walks in nature) from creating highly active stress hormones which slow metabolism.

4. Get enough sleep: Correct the hunger hormones

If you wake up during the night with a sweat it is affecting your sleep, which will increase ghrelin. (the "hunger hormone") and reduce leptin (the "fullness hormone."

  • A sleeping environment that is dark and clean,
  • An end of day practice,
  • Foods rich in magnesium eg. almonds.

At Papayya, our trainers can help fix your form in real time, which helps because joints can feel wobbly.

Lifestyle Accessories That Count

  1. Gut health: Estrogen affects your microbiome. Consume fermented foods and prebiotic fibers to help with digestion and inflammation reduction.
  1. Social connection: Anxiety and loneliness can cause cortisol levels to skyrocket. Connect with supportive groups or coaching from Papayya.
  1. Medications (optional): Certain midlife women take GLP‑1s (such as semaglutide) to aid in weight loss; preliminary studies indicate they suppress appetite and increase metabolic response when taken in combination with HT not for everyone—it's another option to keep in mind.

Role of Estrogen in Regulating Appetite

Estrogen is crucial in appetite regulation given its relationship with certain hunger hormones and brain signaling After the reproductive phase of life, losing estrogen means losing this delicate regulation in hunger, which may lead to the potential for leptin resistance, making it less likely for your brain to get the "full' signal efficiently, plus your body may also be producing more ghrelin (appetite) frankly causing increased hungry and cravings for even more high sugar or high fat foods. Once you realize this change in appetite and hunger, you may eat the normal amount of snacks or meals but not feel satisfied, and therefore continue to eat or continue to eat greater than biases. Eventually, this gradual increase in appetite and food consumption might lead to a considerable increase in calories/food intake over time. This is compounded by the ability to eat inappropriately, especially for emotional or stress-based eating, particularly during the menopause transition in which women may also be experiencing mood changes/deficits, anxiety, etc. Combined, the ability to eat poorly or stress-weighted eating, with the physical effects of diminished estrogen, has everything set-up for weight gain unless you develop a plan for mindful eating and good nutrition.

Misunderstandings about HRT and Weight Gain

Many women are reluctant to pursue Hormone Replacement Therapy (HRT) because of the belief that HRT will lead to weight gain. Many studies have suggested that HRT does NOT cause weight gain, and may even help counter some of the weight and redistribution issues from who experience estrogen deficiency. There is an increase in fat around the abdomen (the ''menopause belly") that occurs with the decrease in estrogen experienced during menopause. 

Why Papayya Is Your Ally Through Midlife

  • Papayya believes midlife wellness isn't about weight lost—it's about softness with strength. 
  • Trainers who are certified in health and physiology, with experience supporting women through menopause. They create strength plans tailored to hormonal changes.
  • 1-on-1 real-time coaching keeps exercise safe and effective
  • Personalized schedules that respond to how you're feeling each day
  • We show you how to blend stress tools, sleep practices, and gut health

The outcome: lasting well-being—not punishment

Midlife Isn't Decline—it's Realignment

  1. Not broken. Not failing. Not behind.
  2. You're in a time of transformation that requires curiosity, compassion, and care.
  3. Midlife weight gain isn't your fault—it's hormonal. But it's not your sentence. It's your signal.
  4. This is your time—to listen, adjust, and find strength aligned with your changing body.

References 

  1. Cleveland Clinic – Menopause and Weight Gain
  1. PubMed – Weight gain and abdominal obesity at menopause
  1. ScienceDirect – Estrogen and energy homeostasis
  1. National Library of Medicine – Estrogen deficiency and obesity
  1. Frontiers in Endocrinology – Estradiol's role in regulating body weight
  1. Mayo Clinic – Menopause weight gain
  1. Menopause Journal – Weight loss response during menopause
  1. Verywell Health – Why menopause makes weight loss harder
  1. Vogue – GLP‑1s & menopausal weight gain

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